Leach Research Group

Current collaborators include AstraZeneca, MedChemica and the NC3Rs.

Current projects involve:

  • Investigating the thermodynamics and kinetics of protein-ligand binding
  • Understanding and applying the reactions of boron-containing compounds in synthetic and medicinal chemistry
  • Quantifying the role of molecular shape in protein-ligand binding
  • Optimising the application of matched molecular pairs analysis
  • Studying the substrate recognition properties of the cytochromes P450
  • Modelling the stability of common reagents used in the pharmaceutical industry
  • Understanding the factors affecting the ability of metal-binding groups to selectively bind to metalloprotein targets.


Our research is primarily computational but driven by close collaborations with medicinal, physical and synthetic chemists.